Endocrine Abstracts

Background: Endemic goiter occurs frequently in iodine deficient areas. Our past medical survey revealed that goiter was endemic in Xinjiang, Northwestern China, because, several elderly Uygur subjects had goiter. In the present study, several medical parameters were compared between subjects with and those without goiter.Methods: Elderly Uygur (age, 65–70 years n=99) and very old Uygur subjects (age, >90 years n=111) were hosp...

Background: Primary aldosteronism (PA) has been reported to affect about 10% of patients with essential hypertension. In Western countries, about one third of them have aldosterone-producing adenomas (APA), and mutations of the KCNJ5 gene have recently been identified in approximately 30% of APAs. In contrast, most Japanese (~80%) with PA have APA. Therefore, Japanese PA may have different characteristics from patients in Western countries, and those with mutations of the KCNJ...